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Simmons & Simmons is undertaking a fresh redundancy consultation that is likely to see around 20 associates and up to 49 secretarial and support staff lose their jobs.
The lawyer redundancies will be in capital markets, banking, projects and real estate.
The firm is also reviewing the positions of 35 secretaries and 12 to 14 professional support staff.
Managing partner Mark Dawkins (pictured) said: "We think our business is changing, particularly in the transactional area.
"We've made the decision to adjust to a changing market."
Dawkins added that, while the firm was reviewing the performance of its partners on an ongoing basis, there were no plans for partner cuts.
This is the second round of job cuts at Simmons, following the loss of eight associates last year. The firm had just completed a three-year review of its wage bill, which saw it invest £25m in its systems and led to the departure of 12 secretaries and nine IT employees (20 October 2008).
This year, Simmons has announced that it will close its Rotterdam office, moving all Dutch lawyers to Amsterdam, and will split with its two-office Portuguese practice.
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