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However, Clifford Chance, led by the firm's head of European competition and regulation Simon Baxter, is reprising its historic role as competition adviser to GE, as the US giant tries again to take on the might of the European Commission.
GE is the magic circle firm's biggest single competition and regulatory client.
GE's last major brush with Brussels occurred during its blocked takeover of Honeywell. However, according to reports, both GE and Amersham expect to gain regulatory approval for the tie-up by the first half of next year.
Aside from its size, the deal, which will see the UK's largest diagnostics group Amersham rolled into the US company to form a division called Healthcare Technologies, is a rarity because not only is it an all-share deal, but also US company takeovers of UK FTSE 100 company are relatively scant.
The team at Slaughters was led by corporate partner Francis Murphy, with partners Jonathan Fenn and Nilufer von Bismarck.